I'm curious about drugs — in particular what happens when you chemically combine methamphetamine and PCP and how it might affect the body. Some places online say they're the same thing, but I'm not so sure.

On "big nights out" (about once a month) friends of mine "plug" ecstasy tablets — by which I mean they each stick one up their butt instead of swallowing.

They claim that is a "safer" way to ingest E because it bypasses the liver and goes right into the bloodstream. They also claim the effects are heightened.

I have been tempted to try this method as they swear by it, but thought I'd get your opinion first — are there any potential side effects to plugging? Is it really a "safer" way to use E?

Recently, I have heard about a new hallucinogen available called salvia dinorium. Some of my friends have tried it and they tell me it is an incredible experience and that when you hallucinate, you have the perception of being brought back in time. Before I even think about trying this, however, I would like to have a more precise idea of what the effects are and what the possible risks of taking salvia are.

Is lsd safe to use while on an SSRI.

Me and my friends are users of X. We know that it's illegal and not good for you, but it's only a once in a while thing. My question is that I know there are different types of X pills that you can take. We have been getting motorolas and I know a friend told me that mitsubishis are really bad to take. I was wondering the differences between the pills and the differences between triple and double stacked pills......

What are the effects of sniffing lighter fluid? I recently had a friend sit in a car to listen to music and smell lighter fluid. He tells me he gets a high from this. What are the effects of doing this? I would appreciate this to educate my friend.

I have two friends who were recently diagnosed with depression. They were both prescribed Prozac by their respective doctors. Both of them are heavy marijuana users and both failed to mention that to their doctors. One has been on Prozac for two months and the other for six weeks. I have noticed that their behavior has become strange: mood swings, paranoia, oversleeping, fatigue. They continue taking their Prozac (20 mg a day) and continue smoking pot. I am afraid that there might be some negative interaction between the substances, one being an antidepressant and the other a depressant. Can you provide some insight?

I have been reading some studies that state a correlation between the "religious experience" generated by the psilocybin in magic mushrooms and LSD, and an alleviation of body dysmorphic, obsessive compulsive, and other related disorders. I was wondering if this is anything being pursued, whether these effects have been proven, and how long the symptoms are alleviated for if this is the case. Are there any specific conditions that must be met in order to avoid a "bad trip"? I know people experiencing any kind of mood disorder are succeptable as such.

My friend recently smoked some pot laced with cocaine. First of all, is this possible? Whatever the case may be, he seems to be infatuated with the idea of trying straight coke. I've heard that trying coke for the first time is quite dangerous, true? Also, what are the effects of the high? And how detrimental is coke in general?

1) I am wondering about the direct effects nitrous oxide has on the brain, and if it is a fallacy that it kills brain cells.

2) What are the health dangers of inhaling nitrous oxide? I have heard people say that it "kills brain cells," but no one seems to know how, to what extent, and what the resulting effects are. Since nitrous oxide is commonly administered as anesthesia, is there a safe way to consume it for recreational use? If the user controls her oxygen intake, do the harmful effects (if any) still occur?

I have a friend at school who quit smoking last year in January, and went back to it in October. I have no idea why, and he also started doing other drugs, such as smoking blunts, doing ecstasy, and taking steroids. The drug that I am worried about him doing the most is ecstasy, because it's a dangerous drug. Also, he is always talking about doing drugs. How can I help him? I still want him to be my friend. Please help. This is serious.

Lately, I have been doing a drug called Special K. I know it is a sedative/tranquilizer (what's the difference?), but very little about side effects, etc. Also, can you go over similar information about the drug X?

I have become interested in trying LSD. But I am worried about what the side effects are and the consequences later in life. I only want to try and have no real need to continue, or desire to, for that matter. I am just really curious. What could happen to me? And do you know where one might find such drugs?

My friend and I snorted a 10 bag each of heroin. Our heads began to feel heavy after ten minutes. Soon we entered into a dream world in which we hallucinated heavily. We talked to people who did not exist and we were very confused. I could not remember anything about who I was. I only remember certain parts of the four-hour trip that followed but I felt like I was on mushrooms for about two days. We could not read for that amount of time (nothing was in focus). What do you think we took? PCP? Bad synthetic heroin?

I have ADHD and am prescribed 30 mg of Ritalin a day. However I also smoke pot at least once a week. Is it okay to be smoking while on Ritalin?

I have two concerns:

My boyfriend claims psychedelics open your mind to new ideas/perspectives and help you experience the "spiritual world." I maintain that anything you see or think is just a result from a brain overloaded on chemicals. However, I am beginning to feel closed-minded, and I would like to have your opinion on psychedelics — are they beneficial if used for a one-time experience, and will they immediately/permanently alter the way I view the world and myself? Given that I have doubts, should I even try anything this mind-altering? I have read your answers pertaining to short-/long-term effects, but I wanted to know if there was any actual evidence of the beneficial effects.

I have heard that people can become trapped in their own world of hallucinations permanently from taking 'shrooms, acid, or other hallucinogens and have to live in a mental health facility because they are so out of touch with reality. I'm wondering is this true? And if so what is this medical condition called? I've heard of Hppd, but what I have read about it, it doesn't sound exactly the same. I'm also curious what the likelihood of this happening would be and if it is dependent on the use of many drugs, dosage, or the user's mental state or other preexisting health conditions that could affect this. I'm really hoping you can answer this question because I haven't found any reliable sources about this topic.

Thanks so much!

Many of my friends take Adderall while they drink. What are the possible health risks of doing this? I know Adderall is a stimulant, so can you drink much more alcohol while on it without feeling the effects as much?

Does acid (LSD) have a detrimental affect on women who use the birth control pill? Is it possible for a woman to be impregnated by pre-ejaculatory fluids four days after the menstrual cycle after unprotected sex?

Are the health risks of drinking Red Bull and vodka in moderation (two to three) drinks an evening any greater than drinking two or three rum and Cokes, or two or three anything and Mountain Dew?

Is it ok to drink alcohol while taking Xanax?

I know that it is extremely dangerous to mix viagra (or other ED drugs) and poppers (amyl nitrate), and that one should wait for 24 hours after using viagra (to let it get out of your system) before using poppers. My question is what is the waiting period after using poppers before it is safe to use viagra? In other words, how long before the physiological effects of poppers wear off?

I've recently dropped acid about 5 times a week for oh... about 3 months now. I have grown mentally and spiritually in ways unimaginable. But friends tell me I am in a false reality now; this brings me off my trip although I now only trip mentally (without the drug). In your opinion, has acid hurt me or helped bring my level of consciousness to a higher level? Am I reaching a state of Nirvana or am I simply a burn out? Please answer this question... I haven't the gall to ask anyone else.

The new acid like synthetic club drug "Foxy" has caught the attention of a few of my friends and I am wondering what kind of high it is — compared to LSD — and what kinds of damage it does to the brain?

I'm a college student who is struggling with the decision on when to see a doctor for treatment with my depression symptoms. I believe that I need to get treated for depression, but I'm just as scared about not getting treatment as I am about starting antidepressant drugs in my current lifestyle. As far as I can tell, I'm exhibiting the classic symptoms of depression, and have been for a while — frequent crying fits, days where I lose all motivation, and sometimes, even thoughts of suicide. But I drink frequently, almost every weekend, and use marijuana occasionally, and I am quite unsettled by the possible interactions between antidepressants and these other substances. In my day to day life I do very well — I hold a good GPA, have good relationships and a good social life, function well most of the time, and stay in shape for sports. I don't intend to change my lifestyle significantly to make room for depression treatment. But when do I need to get help? I don't want to force an unnecessary change on myself, but I don't want to put myself in danger from depression, or even worse, from the drug interactions between antidepressants and alcohol or weed. What is the tipping point?