My friend recently smoked some pot laced with cocaine. First of all, is this possible? Whatever the case may be, he seems to be infatuated with the idea of trying straight coke. I've heard that trying coke for the first time is quite dangerous, true? Also, what are the effects of the high? And how detrimental is coke in general?

Could you possibly tell me the interactive effects of Zoloft (the anti-depressant) and MDMA (Ecstasy)?

I used to be a heavy ecstasy user and now am clean from ecstasy. I find I can't ejaculate. Alice, I guess my question is would the ecstasy have affected me sexually, so that I can't ejaculate when I'm having sex?

I am a teenage girl currently taking Adderall (20 mg) to treat my ADHD. My question: does taking this medication affect sexual wantings or behavior? I am supposed to start taking it at 7:00am so it will wear out at about 9:00 or 9:30pm. Since I go out later at night, my medicine is usually worn off before I engage in any kind of sexual activity. But sometimes on weekends I wake up late and have to take it at later times such as 12:00 or 1:00pm. Since then it will not wear off until after I go out, would being on Adderall affect my sexual behavior? I feel like I am less "horny" when on Adderall and sex is worse because of the lack of my desires. Does this have anything to do with my medicine or is it just a coincidence?

I have a huge dilemma. I have an addiction to a certain drug that has turned my life upside down. That drug is crack cocaine. The worst part about it is that nobody knows this but me. Nobody knows that right now, my life is on the brink. How do you express this problem to people who don't even have a clue as to what you are dealing with? How do you reach out to the people who you love and trust when you are so ashamed of the truth? One thing that I do know is that I'd better do something fast because if I don't, I will lose my fight with life. HELP!!

I have been trying to find information about the hope for recovery for previous meth users, but there doesn't seem to be a consensus. Some sources say that meth causes permanent damage to the brain, while others are a little more hopeful and say some important brain functions might recover.

I used meth about fifteen times, which I gather isn't a lot in comparison to other meth users but is still a considerable amount. For a while I have felt paranoid and anxious and it has been more difficult to perform daily tasks and just generally think straight. Also, things I used to enjoy are not really that enjoyable anymore.

My question is, will I be able to have my brain back? If so, how much of it? Will I ever go back to being my old self?

I originally took a muscle relaxer because I was experiencing very bad back pain and could not sleep. I was not prescribed the muscle relaxers. My friend suggested I take one of hers. So I did, and now I will take one sometimes before bed if I can't fall asleep or if I want to actually just relax. It makes me just want to sleep, and I feel really calm after taking one. Is this bad that I take them for this reason? What are the side effects? Is it harmful?

1) I have a large amount of course work, which is combined with a job and extra-curriculars, and while I want to succeed in all of them, I find that I simply don't have enough time, even though I currently sleep only 4 or 5 hours a night. I mentioned this to a group of my friends here at school, and it turns out they all take stimulants to help them manage jam-packed undergraduate life. The pills are called ADDERALL and PROVIGIL. I have acquired some for myself, but before I take them, could you tell me if either has serious health risks? I do not have any other health problems or take any other medications. A few of my friends tell me that they sometimes stay awake for as long as 3 or 4 days. If it is reasonably safe, that would be great! Thank you.

2) Given the fact that this is a top-notch school, it's total hoo-ha that you haven't included any info on all the non-hard core, but still illegal, "study stimulants." Is all this ADDERALL gonna do me permanent damage or what?

I have been taking between 5 and 10 mgs of methadone daily. I cannot seem to stop. Every time I try, I get very, very depressed and experience abdominal pain, chills, hot flashes, and sleeplessness. The depression and tremendous anxiety are intolerable and I end up taking more to avoid it. Question: Am I harming my body and/or mind with this stuff? How can I get off without the horrible feelings?

My friend and I snorted a 10 bag each of heroin. Our heads began to feel heavy after ten minutes. Soon we entered into a dream world in which we hallucinated heavily. We talked to people who did not exist and we were very confused. I could not remember anything about who I was. I only remember certain parts of the four-hour trip that followed but I felt like I was on mushrooms for about two days. We could not read for that amount of time (nothing was in focus). What do you think we took? PCP? Bad synthetic heroin?