On "big nights out" (about once a month) friends of mine "plug" ecstasy tablets — by which I mean they each stick one up their butt instead of swallowing.

They claim that is a "safer" way to ingest E because it bypasses the liver and goes right into the bloodstream. They also claim the effects are heightened.

I have been tempted to try this method as they swear by it, but thought I'd get your opinion first — are there any potential side effects to plugging? Is it really a "safer" way to use E?

Hi, where can I test my molly on or near campus?

Me and my friends are users of X. We know that it's illegal and not good for you, but it's only a once in a while thing. My question is that I know there are different types of X pills that you can take. We have been getting motorolas and I know a friend told me that mitsubishis are really bad to take. I was wondering the differences between the pills and the differences between triple and double stacked pills......

I heard that the first reaction you have to taking ecstasy is to become violently ill, after which the party can continue. This sounds like an urban legend to me. Could you clarify please?

Recently, my boyfriend began injecting cocaine. I've noticed that he and his friends share their needles, but "clean" them first with bleach and water. Is this a valid way to avoid contamination?

My friend recently smoked some pot laced with cocaine. First of all, is this possible? Whatever the case may be, he seems to be infatuated with the idea of trying straight coke. I've heard that trying coke for the first time is quite dangerous, true? Also, what are the effects of the high? And how detrimental is coke in general?

Could you possibly tell me the interactive effects of Zoloft (the anti-depressant) and MDMA (Ecstasy)?

I used to be a heavy ecstasy user and now am clean from ecstasy. I find I can't ejaculate. Alice, I guess my question is would the ecstasy have affected me sexually, so that I can't ejaculate when I'm having sex?

I have a huge dilemma. I have an addiction to a certain drug that has turned my life upside down. That drug is crack cocaine. The worst part about it is that nobody knows this but me. Nobody knows that right now, my life is on the brink. How do you express this problem to people who don't even have a clue as to what you are dealing with? How do you reach out to the people who you love and trust when you are so ashamed of the truth? One thing that I do know is that I'd better do something fast because if I don't, I will lose my fight with life. HELP!!

I have been trying to find information about the hope for recovery for previous meth users, but there doesn't seem to be a consensus. Some sources say that meth causes permanent damage to the brain, while others are a little more hopeful and say some important brain functions might recover.

I used meth about fifteen times, which I gather isn't a lot in comparison to other meth users but is still a considerable amount. For a while I have felt paranoid and anxious and it has been more difficult to perform daily tasks and just generally think straight. Also, things I used to enjoy are not really that enjoyable anymore.

My question is, will I be able to have my brain back? If so, how much of it? Will I ever go back to being my old self?

My dad requires me to take weekly drug tests since he found out that I was smoking marijuana. My first test came back positive for marijuana and cocaine. I was not surprised about the marijuana because I had only been clean for five weeks, but I have never done cocaine. Is there anything that could have triggered a positive result? Could opium or mushrooms or any other drug possibly trigger this positive result?

1) I found a white powder in my friend's car and I think it might be cocaine. I'm not sure if it is or not. I don't know if I should confront him with it or what I should do. I don't want to see my friend get hurt, but if I'm wrong, I don't want to falsely accuse him of something like this. How should I go about handling the situation?

2) I am a first-year business student and have a little sister who is a junior. I think she is doing cocaine because I found some "paraphernalia" in her room last week. What can I do without damaging my relationship with her?

Does ecstasy drain spinal fluid? Or is this a dumb myth?

My friend recently told me that she has a serious blow problem. She lives with her boyfriend and she said that all they do is work, sleep, and blow. By telling me this I understand that she has taken some very important steps into wanting to get better, but I'm completely useless in trying to help because I just don't know enough about the drug and rehab and ways to support her.

So far I've made the suggestion that she come spend some time with me and away from home so that the reminder of it is lessened, I can prevent her from bringing it in, and can try and keep her occupied to take her mind off it. What else can you suggest?

Is there any way to stop an E come down, or at least make it so I don't feel rough all day the next day?

Recently, many of my friends have been doing methamphetamines. Often when they start to come down, want to come down, want to "level" out their high, etc. they take Xanax!!! Now I know Xanax is an anti-anxiety drug, and meth speeds your heart up. So can mixing the two ("reds" with "blues") be especially bad? I keep trying to tell them that it doesn't sound like a good idea...but they know that I hate pills so they DON'T listen. "They know better!" But I haven't been able to find any info specific to my question in other places. CAN YOU HELP?